In vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp., and Malassezia pachydermatis (Pityrosporum canis). The primary action of clotrimazole is against dividing and growing organisms. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids.Д¬lotrimazole: Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes and yeasts. Inflammation can increase percutaneous absorption. Topical corticosteroids can be absorbed from normal, intact skin. Betamethasone valerate, the 17-valerate ester of betamethasone, has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid-responsive otitis externa. Betamethasone, an analog of prednisolone, has a high degree of corticosteroid activity and a slight degree of mineralocorticosteroid activity. Specifically, gentamicin is active against the following organisms commonly isolated from canine ears: Staphylococcus aureus, other Staphylococcus spp., Pseudomonas aeruginosa, Proteus spp., and Escherichia coli.Д«etamethasone: Betamethasone valerate is a synthetic adrenocorticoid for dermatologic use. In vitro tests have determined that gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. Gentamicin: Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of pathogenic gram-negative and gram-positive bacteria.

DescriptionД®ach gram of OTOMAX ointment contains gentamicin sulfate, equivalent to 3В mg gentamicin base betamethasone valerate, equivalent to 1 mg betamethasone and 10 mg clotrimazole, in a mineral oil-based system containing a plasticized hydrocarbon gel. Keep this and all drugs out of the reach of children. (GENTAMICIN SULFATE, BETAMETHASONE VALERATE AND CLOTRIMAZOLE, OINTMENT)Д¬AUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

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